Beta-Hydroxyisovaleric acid ( —— )

产品货号. M15365 CAS No. 625-08-1

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

Beta-Hydroxyisovaleric acid
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

3-Hydroxyisovaleric acid 是尿液中排泄的正常内源性代谢产物 (endogenous metabolite)。3-Hydroxyisovaleric acid 的尿排泄是生物素缺乏的早期和敏感指标。
产品描述

Used as pharmaceutical intermediates.
体外实验

The reduced activity of methylcrotonyl-CoA carboxylase (MCC) leads to an elevated excretion of 3-methylcrotonic acid, the product of its hydration (3-hydroxyisovaleric acid: 3-HIA), and 3-methylcrotonylglycine, formed by conjugation with glycine.
体内实验

In male mice (ICR/Jcl) at 8 weeks of age fed the biotin-deficient diet for 6 weeks, the concentration of urinary 3-Hydroxyisovaleric acid is 114.2 mM creatinine, which is higher than the concentration of 35.2 mM creatinine in mice fed the biotin-deficient diet for 4 weeks.
同义词

——
通路

Others
靶点

Other Targets
受体

Others
研究领域

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适应症

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1. Sabourin PJ, Bieber LL. Arch Biochem Biophys. 1981 Jan;206(1):132-44.

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